A: In Short, Yes a Locksmith can make a key without the original.
An experienced Honda Accord locksmith will be able to make a replacement key for you even if you do not have the original. When you contact a locksmith, you will need to supply some information to the company before your key can be replaced.
If you lose the key and fob and you don’t have a spare you can expect a dealer replacement and programming to cost $200 or more, depending on the vehicle and the key’s design. A Honda Accord dealer quoted $374 for a new key, fob, and programming.